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  • dr Victor Enrique Corona

Nutrition suggestions for prostate cancer patients. Part I.

Updated: Nov 30, 2019

The below suggestions is a compendium of information taken from

currently available scientific studies on the influence of the different

nutrition on prostate cancer patients. Some products seems to lower

the risk of development or progression of the disease and some

increase this risk.


Products decreasing the risk:


Tomatoes

In a series of studies tomato juice, sauce, paste taken everyday has

found to be significantly suppressing prostate cancer cell growth.

Some studies showed also drop of the PSA level. This effect is most

probably caused by powerful antioxidant – substance called lycopene

and other carotenoids contained in tomato.


Plant-based high fibre diet

Multiple studies also show possible risk decreasing effect - slow down

or even reverse of the progression of prostate cancer cell growth with

the increased intake of whole grains, vegetables (especially

cruciferous ), fruit, beans, seeds, legumes, nuts, peas, raisin, dates.

Generally, the more consistent and disciplined was change of diet,

the stronger improvements in health conditions occurred.


Soy products

Soy milk and diet rich in soy products was studied buy numerous

scientists in the environments naturally consuming them more then in

western diet (Japanese and other Asian countries, Adventists

community). The results show very significant reduction of the

prostate cancer development risk. Phytoestrogens in soy, slow down 3

prostate cancer cell grow and their spread to the other organs -

metastasis.


Green Tea

Different studies also confirmed efficiency of the high (about 6 cups a

day) consumption of the green tea in stopping prostate cancer from

developing. Black tee did not show any similar effect.


Fish

Traditional Japanese diet is rich in fish and that has also shown to

decrease prostate cancer risk in some men. Long term population

based studies suggest that men, who eat fish more than 3 times a

week can lower the risk of developing and progressing of prostate

cancer or prostate cancer related mortality.


Pomegranate

Studies done in lab and on mouses had shown significant slowdown in

prostate cancer cells growth together with strong drop down of the

PSA levels when human prostatectomy cancer cells where treated

with pomegranate juice extract. The suggestion out of those studies

is, that pomegranate mighty have therapeutic effect on prostate

cancer in people.


Fruit, fructose

High fructose intake in some studies was related to a lower risk of

advanced prostate cancer.


Supplemental and Dietary Selenium Se

Some trials showed reduction of the prostate cancer risk among

men, who had initial low selenium blood level. Other study showed

that Se supplementation may increase the destruction of the prostate cancer cells. Especially beneficial was dietary selenium.


Dietary Omega3 Fatty Acids

Protective effect of the dietary Omega 3 was noticed by serious of

the studies.


!!!!!! In a Part II the Products, that can increase the risk.


Reference:


Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer Arshi Malik, Farrukh Afaq, Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, and Hasan Mukhtar, PNAS October 11, 2005 102 (41) 14813-14818; https://doi.org/ 10.1073/pnas.0505870102


Pomegranate Extracts Potently Suppress Proliferation, Xenograft Growth, and Invasion of Human Prostate Cancer Cells Martin Albrecht, Wenguo Jiang, James Kumi-Diaka, Ephraim P. Lansky, Lyndon M. Gommersall, Amit Patel, Robert E. Mansel, Ishak Neeman, Albert A. Geldof, and

Moray J. Campbell, Published Online:24 Sep 2004https://doi.org/10.1089/jmf. 2004.7.274


Prostate cancer prevention through pomegranate fruit

(PMID:16479165), Malik A , Mukhtar H, Cell Cycle (Georgetown, Tex.) [15 Feb 2006, 5(4):371-373], Type: Journal Article DOI: 10.4161/cc.5.4.2486


Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland Navindra P. Seeram*,William J. Aronson, Yanjun Zhang, Susanne M. Henning, Aune Moro, Ru-po Lee, Maryam Sartippour, Diane M. Harris, Matthew Rettig, Marc A. Suchard∥Allan J. Pantuck, Arie Belldegrun, David Heber


Fatty fish consumption and risk of prostate cancer A Prospective Study of Intake of Fish and Marine Fatty Acids and Prostate Cancer Katarina Augustsson, Dominique S. Michaud, Eric B. Rimm, Michael F. Leitzmann, Meir J. Stampfer, Walter C. Willett and Edward Giovannucci, Published January 2003


Fish consumption and prostate cancer risk: a review and meta-analysis

Konrad M Szymanski, David C Wheeler, Lorelei A Mucci, The American Journal of Clinical Nutrition, Volume 92, Issue 5, November 2010, Pages 1223– 1233,


Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer William J Aronsona,*correspondence, John A Glaspyb, Srinivasa T Reddyc, David Reesed, David Hebere, Dilprit Baggab


Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study Stella Koutros, Amanda J. Cross, Dale P. Sandler, Jane A. Hoppin, Xiaomei Ma, Tongzhang Zheng, Michael C.R. Alavanja and Rashmi Sinha


Meat and Meat-related Compounds and Risk of Prostate Cancer in a Large Prospective Cohort Study in the United States, Rashmi Sinha, Yikyung Park, Barry I. Graubard, Michael F. Leitzmann, Albert Hollenbeck, Arthur Schatzkin, Amanda J. Cross, American Journal of Epidemiology, Volume 170, Issue 9, 1 November 2009, Pages 1165–1177


Meat Consumption, Cooking Practices, Meat Mutagens, and Risk of Prostate Cancer Esther M. John, Mariana C. Stern, Rashmi Sinha & Jocelyn Koo (2011)Nutrition and Cancer, 63:4, 525-537, DOI: 10.1080/01635581.2011.53931


Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study

Sabine RohrmannElizabeth A. PlatzEmail authorClaudine J. KavanaughLucy ThuitaSandra C. HoffmanKathy J. Helzlsouer



Prospective Studies of Dairy Product and Calcium Intakes and Prostate CancerXiang Gao, Michael P. LaValley, Katherine L. Tuckerisk: A Meta-Analysis, JNCI: Journal of the National Cancer Institute, Volume 97, Issue 23, 7 December 2005, Pages 1768– 1777,


Dietary fat intake and prostate cancer risk: a case–control study in Spain

Ramon, J.M., Bou, R., Romea, S. et al. Cancer Causes Control (2000) 11: 679.


Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study, June M Chan, Meir J Stampfer, Jing Ma, Peter H Gann, J Michael Gaziano, Edward L Giovannucci, The American Journal of Clinical Nutrition, Volume 74, Issue 4, October 2001, Pages 549– 554,


Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition N E Allen, TJ Key, E Roboli, British Journal of Cancer volume 98, pages1574–1581 (06 May 2008)


Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies Dagfinn Aune, Deborah A Navarro Rosenblatt, Doris SM Chan, Ana Rita Vieira, Rui Vieira, Darren C Greenwood, Lars J Vatten, Teresa Norat, The American Journal of Clinical Nutrition, Volume 101, Issue 1, January 2015, Pages 87–117, https:// doi.org/10.3945/ajcn.113.067157


Calcium, Diary Products and Risk of Prostate Cancer in a Prospective Cohort of United States Men Carmen Rodriguez, Marjorie L. McCullough, Alison M. Mondul, Eric J. Jacobs, Dorna Fakhrabadi-Shokoohi, Edward L. Giovannucci, Michael J. Thun and Eugenia E. Calle


Fruit and Vegetable Intakes and Prostate Cancer Risk

Jennifer H. Cohen, Alan R. Kristal, Janet L. Stanford,, JNCI: Journal of the National Cancer Institute, Volume 92, Issue 1, 5 January 2000, Pages 61–68, https://doi.org/ 10.1093/jnci/92.1.61


Vegetables, Fruits, Legumes and Prostate Cancer: A Multiethnic Case-Control Study Laurence N. Kolonel, Jean H. Hankin, Alice S. Whittemore, Anna H. Wu, Richard P. Gallagher, Lynne R. Wilkens, Esther M. John, Geoffrey R. Howe, Darlene M. Dreon, Dee W. West and Ralph S. Paffenbarger J.


Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Eric A. Klein, MD; Ian M. Thompson, MD; Catherine M. Tangen, DrPH; JAMA. 2011;306(14):1549-1556. doi:10.1001/jama.2011.1437


Vitamins E and C in the Prevention of Prostate and Total Cancer in Men The Physicians' Health Study II Randomized Controlled Trial Susanne Rautiainen, PhD; J. Michael Gaziano, MD, MPH; William G. Christen, ScD; Vadim Bubes, PhD; Gregory Kotler, PhD; Robert J. Glynn, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; Howard D. Sesso, ScD, MPH


Supplemental and Dietary Vitamin E, β-Carotene, and Vitamin C Intakes and Prostate Cancer Risk Victoria A. Kirsh, Richard B. Hayes, Susan T. Mayne, Nilanjan Chatterjee, Amy F. Subar, L. Beth Dixon, Demetrius Albanes, Gerald L. Andriole, Donald A. Urban, Ulrike Peters On behalf of the PLCO Trial

JNCI: Journal of the National Cancer Institute, Volume 98, Issue 4, 15 February 2006, Pages 245–254, https://doi.org/10.1093/jnci/djj050


Status of selenium in prostate cancer prevention

Combs, G. Br J Cancer 91, 195–199 (2004) doi:10.1038/sj.bjc.6601974


Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk Vincent Fradet, Iona Cheng, Graham Casey and John S. Witte DOI: 10.1158/1078-0432.CCR-08-2503 Published April 2009


Omega-3 Fatty Acids and PPAR in Cancer

Iris J. Edwards1 and Joseph T. O'Flaherty2 1Departments of Pathology, Wake Forest University School of Medicine, Winston- Salem, NC 27157, USA 2Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA


Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer Arshi Malik, Farrukh Afaq, Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, and Hasan Mukhtar, PNAS October 11, 2005 102 (41) 14813-14818; https://doi.org/ 10.1073/pnas.0505870102


Plant Foods, Antioxidants, and Prostate Cancer Risk: Findings From Case-Control Studies in Canada Meera G. Jain , Gregory T. Hislop , Geoffrey R. Howe & Parviz Ghadirian Pages 173-184 | Published online: 18 Nov 2009Download citation https://doi.org/ 10.1207/S15327914NC3402_8


Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis

Lin Yan, Edward L Spitznagel The American Journal of Clinical Nutrition, Volume 89, Issue 4, April 2009, Pages 1155–1163, https://doi.org/10.3945/ajcn.2008.27029


Calcium and Fructose Intake in Relation to Risk of Prostate Cancer

Edward Giovannucci, Eric B. Rimm, Alicja Wolk, Alberto Ascherio, Meir J. Stampfer, Graham A. Colditz and Walter C. Willett Published February 1998


Fruit and Vegetable Intakes and Prostate Cancer Risk

Jennifer H. Cohen, Alan R. Kristal, Janet L. Stanford JNCI: Journal of the National Cancer Institute, Volume 92, Issue 1, 5 January 2000, Pages 61–68, https://doi.org/10.1093/jnci/92.1.61


The role of diet in prostate cancer

Lalita Kaul , Martin Y. Heshmat , Joseph Kovi , Marvin A. Jackson , Aaron G. Jackson George W. Jones , Mitchell Edson , John P. Enterline , Roger G. Worrell & Sophie L. Perry, Nutrition and Cancer, Volume 9, 1987 - Issue 2-3


Case-control study of diet and prostate cancer in China

Marion M. Lee Run-Tian Wang Ann W. Hsing Fung-Liu Gu Tao Wang Margaret Spitz


Diet and prostate cancer

Tomoyuki Shirai Makoto Asamoto SatoruTakahashi Katsumi Imaida https://doi.org/10.1016/S0300-483X(02)00260-3


A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet Tomoko Sonoda Yoshie Nagata Mitsuru Mori Naoto Miyanaga ... First published: 19 August 2005 https://doi.org/10.1111/j.1349-7006.2004.tb02209.x


Impact of diet on prostate cancer: a review

G A Sonn, W Aronson & M S Litwin Prostate Cancer and Prostatic Diseases volume 8, pages 304–310 (2005)


Oxidative DNA damage in prostate cancer patients consuming tomato sauce- based entrees as a whole-food intervention Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R, Ashton D, Bowen PE.. J Natl Cancer Inst. 2001 Dec 19;93(24):1872-9.


Arachidonic acid stimulates prostate cancer cell growth: critical role of 5- lipoxygenase Ghosh J, Myers CE.. Biochem Biophys Res Commun. 1997 Jun 18;235(2):418-23.


Potential attenuation of disease progression in recurrent prostate cancer with plant-based diet and stress reduction Saxe GA, Major JM, Nguyen JY, Freeman KM, Downs TM, Salem CE.. Integr Cancer Ther. 2006 Sep;5(3):206-13.


Intensive lifestyle changes may affect the progression of prostate cancer.

Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ, Dunn-Emke S, Crutchfield L, Jacobs FN, Barnard RJ, Aronson WJ, McCormac P, McKnight DJ, Fein

JD, Dnistrian AM, Weinstein J, Ngo TH, Mendell NR, Carroll PR. J Urol. 2005 Sep; 174(3):1065-9; discussion 1069-70.


Can diet in conjunction with stress reduction affect the rate of increase in prostate specific antigen after biochemical recurrence of prostate cancer?Saxe GA, Hébert JR, Carmody JF, Kabat-Zinn J, Rosenzweig PH, Jarzobski D, Reed GW, Blute RD. J Urol. 2001 Dec;166(6):2202-7.


Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis.


Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention Kumar NB, Pow-Sang J, Egan KM, Spiess PE, Dickinson S, Salup R, Helal M, McLarty J, Williams CR, Schreiber F, Parnes HL, Sebti S, Kazi A, Kang L, Quinn G, Smith T, Yue B, Diaz K, Chornokur G, Crocker T, Schell MJ.. Cancer Prev Res (Phila). 2015 Oct;8(10):


Green tea and prostate cancer: from bench to clinic.

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Cohort study of diet, lifestyle, and prostate cancer in adventist men.

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Role of Diet in Prostate Cancer Development and Progression

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Images used are courtesy of pixabay.com

1 „Carotenoids are pigments in plants, algae, and photosynthetic bacteria. These pigments produce the bright yellow, red, and orange colors in plants, vegetables, and fruits". Carotenoids act as a type of antioxidant for humans. 2 cauliflower, cabbage, garden cress, bok choy, broccoli, brussels sprouts and similar green leaf vegetables

3 “Phytoestrogens are compounds that naturally occur in plants. They're also found in a wide range of plant foods. If you eat fruits, veggies, legumes, and some grains, you get phytoestrogens from your diet. A plant-based diet is very rich in natural phytoestrogensin healthy amounts, especially from soy.”


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